|
T8548 |
Metoprine
|
|
Histone Methyltransferase
,
Antifolate
,
Histamine Receptor
|
|
Metoprine is a potent inhibitor of histamine N-methyltransferase (HMT), with potential antineoplastic activity. |
|
T22782 |
FGIN-1-27
|
|
Others
|
|
high affinity agonist of the translocator protein |
|
T2625 |
MK-0752
|
|
Beta Amyloid
,
Gamma-secretase
|
|
MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM). |
|
T15108 |
DG-041
|
|
Prostaglandin Receptor
|
|
DG-041 is an antagonist of high-affinity EP3 receptor (IC50s: 4.6 nM and 8.1 nM in the binding and FLIPR assay, respectively). DG-041 inhibits PGE2 facilitation of platelet aggregation and has the blood-brain barrier per... |
|
T8778 |
TTK21
|
|
Epigenetic Reader Domain
|
|
TTK21 is an activator of CBP/p300 histone acetyltransferase activity. |
|
T2009 |
SB-3CT
|
|
MMP
|
|
SB-3CT is a potent and specific gelatinase inhibitor for MMP-2(Ki=13.9 nM) and MMP-9(Ki=600 nM). |
|
T1993 |
J-147
|
J147 |
Epigenetic Reader Domain
,
Dopamine Receptor
,
Monoamine Oxidase
|
|
J-147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative and a potent neurogenic and neuroprotective drug candidate... |
|
T3119 |
JNJ-63533054
|
JNJ 63533054 |
GPR
|
|
JNJ-63533054 is a potent and selective agonist of hGPR139 with an EC50 = 16 nM. |
|
T24055 |
FAUC 213
|
FAUC213,FAUC-213 |
Dopamine Receptor
|
|
FAUC 213 is a selective full antagonist of the dopamine D4 receptor. |
|
T9687 |
MAGL-IN-4
|
His121 ARG57 |
Lipase
|
|
MAGL-IN-4 (His121 ARG57) is one of the monoacylglycerol lipase (MAGL) inhibitors in central nervous system-related diseases. |
|
T1065 |
Baclofen
|
Lioresal |
GABA Receptor
|
|
Baclofen (Lioresal) is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen acts as a gamma-aminobutyric acid (GABA) agonist sp... |
|
T0082 |
Domperidone
|
R33812 |
Dopamine Receptor
|
|
Domperidone (R33812)(Motilium) is a dopamine blocker and an antidopaminergic reagent. It blocks the action of. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger z... |
|
T12877L |
Seltorexant
|
JNJ-42847922 |
OX Receptor
|
|
Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain. Seltorexant is a high-affinity and selective orexin-2 receptor antagonist (pKi: 8.0 and 8.1 for human a... |
|
T2684 |
JNJ-1661010
|
JNJ1661010,Takeda-25,JNJ 1661010 |
FAAH
|
|
JNJ-1661010 (Takeda-25) is an effective and specific FAAH inhibitor (IC50: 10/ 12 nM for rat/human), shows >100-fold selectivity for FAAH-1 than FAAH-2. |
|
T2316 |
Omarigliptin
|
MK-3102 |
Proteasome
,
DPP-4
|
|
Omarigliptin (MK-3102) has been used in trials studying the treatment of Type 2 Diabetes Mellitus and Chronic Renal Insufficiency. |
|
T21935L |
AMN082 free base
|
AMN082 |
GluR
|
|
AMN082 free base is a metabotropic glutamate receptor 7 allosteric agonist. |
|
T8526 |
Metformin
|
1,1-Dimethylbiguanide |
Mitophagy
,
AMPK
,
Autophagy
|
|
Metformin (1,1-Dimethylbiguanide) is an AMPK activator with blood-brain barrier permeability. Metformin may improve glycemic control by increasing insulin sensitivity and decreasing intestinal glucose uptake, and is comm... |
|
T11861 |
LM11A-31 dihydrochloride
|
|
Others
|
|
LM11A-31 dihydrochloride is a water-soluble, non-peptide with high blood-brain barrier permeability.LM11A-31 dihydrochloride, a p75NTR (neurotrophin receptor p75) Ligand, is a potent proNGF (nerve growth factor) antagoni... |
|
T12492 |
Pivagabine
|
CXB-722 |
GABA Receptor
|
|
Pivagabine (CXB-722), a hydrophobic 4-aminobutyric acid derivative, exhibits neuromodulatory activity and successfully penetrates the blood-brain barrier in rats. It counteracts the impact of foot shock on GABAA receptor... |
|
T23394 |
SR 57227A
|
SR 57227 hydrochloride |
5-HT Receptor
|
|
SR 57227A (SR 57227 hydrochloride) is a potent, orally active and selective 5-HT3 receptor agonist. It with ability to cross the blood brain barrier. It has affinities (IC50) varying between 2.8 and 250 nM for 5-HT3 rece... |
|
T2141 |
Mecamylamine hydrochloride
|
Inversine,Mevasin |
AChR
|
|
Mecamylamine hydrochloride (Mevasin) is a nicotinic antagonist, used as a ganglionic blocker in hypertension. |
|
T21422 |
Methylnaltrexone bromide
|
Relistor,MOA-728,MOA 728,Methylnaltrexone,MOA728 |
Opioid Receptor
|
|
Methylnaltrexone bromide (MOA-728) is one of the newer agents of peripherally-acting μ-opioid antagonists. Methylnaltrexone bromide acts to reverse some of the side effects of opioid drugs such as constipation without af... |
|
T13664 |
DSP-4 hydrochloride
|
Neurotoxin DSP 4 (hydrochloride) |
Others
|
|
DSP-4 hydrochloride (Neurotoxin DSP 4 (hydrochloride)) (Neurotoxin DSP 4 hydrochloride) can be used for the temporary selective degradation of the central and peripheral noradrenergic neurons, mainly those from the locus... |
|
T8630 |
Baclofen hydrochloride
|
4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride |
GABA Receptor
|
|
Baclofen hydrochloride (4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride) is a GAMMA-AMINOBUTYRIC ACID derivative that is a specific GABA-B RECEPTORS agonist. It is used in the treatment of MUSCLE SPASTICITY, espe... |
|
T20570 |
Labetalol
|
Apo-Labetalol,Albetol,Trandate,Dilevalol,Normodyne |
Adrenergic Receptor
|
|
Labetalol (Apo-Labetalol) is a mixed alpha/beta-adrenergic antagonist.It is used to treat high blood pressure. It can be given by mouth for long term hypertension management or intravenously in severe hypertensive situat... |
|
T7601L |
Carbetocin acetate
|
Carbetocin acetate(37025-55-1 free base) |
Oxytocin Receptor
|
|
Carbetocin acetate is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth. |
|
T6438 |
Cefoselis Sulfate
|
FK 037 Sulfate,FK-037 |
Antibacterial
,
Antibiotic
|
|
Cefoselis Sulfate is a widely used beta-lactam antibiotic. |
|
T11571 |
HLY78
|
4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine |
Wnt/beta-catenin
|
|
HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) targets the DIX domain of Axin, is an activator of the Wnt/β-catenin signaling pathway and can enhance Axin-LRP6 binding to promote Wnt signaling. |
|
T0740 |
Metformin hydrochloride
|
Metformin HCl,1, 1-Dimethylbiguanide hydrochloride,1,1-Dimethylbiguanide hydrochloride |
Mitophagy
,
AMPK
,
Autophagy
|
|
Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) , a widely used anti-diabetic drug, has a potential function as an anti-Y medicine. It inhibits the proliferation of a variety of Y cells including colon, pro... |
|
T1667 |
Tandutinib
|
MLN518,CT53518,NSC726292 |
Apoptosis
,
FLT
,
CSF-1R
,
PDGFR
,
Src
,
c-Kit
|
|
Tandutinib (CT53518) (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versu... |
|
T0825 |
Ebselen
|
SPI-1005,PZ-51,CCG-39161 |
Phosphatase
,
Virus Protease
,
Calcium Channel
,
COX
,
HIV Protease
|
|
Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced b... |
|
T7601 |
Carbetocin
|
|
Oxytocin Receptor
|
|
Carbetocin is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth. |
|
T21935 |
AMN082
|
AMN 082 dihydrochloride |
GluR
|
|
AMN082 (AMN 082 dihydrochloride) is a selective metabotropic glutamate mGlu7 receptor agonist reported to exhibit antidepressant activity. |
|
T12017 |
Methyllycaconitine citrate
|
MLA |
AChR
|
|
Methyllycaconitine citrate (MLA) is an α7 neuronal nicotinic acetylcholine receptor (α7nAChR) antagonist that crosses the blood-brain barrier. |
|
T6845 |
GNE-317
|
GNE317 |
PI3K
,
mTOR
|
|
GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB). |
|
T15779 |
LP-533401 hydrochloride
|
|
5-HT Receptor
|
|
LP-533401 hydrochloride is a peripheral Tph inhibitor that cannot cross the blood-brain barrier
that inhibits 5-hydroxytryptamine synthesis and can be used to study periodontal disease and hepatic steatosis. |
|
TQ0026 |
MDR-1339
|
DWK-1339 |
Beta Amyloid
,
Gamma-secretase
|
|
|
|
T17211 |
Vafidemstat
|
ORY-2001 |
Histone Demethylase
,
MAO
|
|
Vafidemstat (ORY-2001) is a selective, orally active lysyl-histone demethylase (LSD1)/MAO-B inhibitor that crosses the blood-brain barrier for the study of neurological diseases. |
|
T5518 |
N-acetylcysteine amide
|
|
Reactive Oxygen Species
,
ROS
|
|
N-Acetylcysteine amide is a thiol antioxidant and neuroprotective agent that can permeate cell membranes and the blood-brain barrier. |
|
T1612 |
Neostigmine methyl sulfate
|
Normastigmin,Hodostin,Syntostigmin |
AChR
,
AChE
|
|
Neostigmine methyl sulfate (Syntostigmin) is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier, used in the treatment of myasthenia gravis. |
|
T10855 |
CO23
|
|
Thyroid hormone receptor(THR)
|
|
CO23 is a blood-brain barrier penetrant and selective TRα agonist and can be used in studies about the regulation of growth and development. |
|
T35559 |
SAG 21k
|
|
Hedgehog/Smoothened
|
|
SAG 21k is an orally bioactive and potent Hedgehog signaling activator that crosses the blood-brain barrier for the study of cartilage regeneration. |
|
T33467 |
MOMIPP
|
|
PI3K
|
|
MOMIPP is a PIKfyve inhibitor and a macropinocytosis inducer. MOMIPP readily penetrates the blood-brain barrier and is moderately effective in suppressing progression of intracerebral glioblastoma xenografts[1][2]. |
|
T2708 |
SL327
|
SL 327,SL-327 |
MEK
,
DNA/RNA Synthesis
|
|
SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier. |
|
T7340 |
5'-N-Ethylcarboxamidoadenosine
|
NECA |
Adenosine Receptor
|
|
5'-N-Ethylcarboxamidoadenosine (NECA) is an agonist of Adenosine receptor, increases cerebral extravasation of fluorescein and low molecular weight dextran independent of blood-brain barrier modulation. |
|
T33535 |
MW01-2-151SRM
|
MW 151,MW-151,MW012151SRM,MW151,MW01 2 151SRM |
Others
|
|
MW01-2-151SRM is a novel small molecule inhibitor of microglia activation that crosses the blood-brain barrier, has anti-neuroinflammatory effects, attenuates the up-regulation of glial cytokines in models of neuroinflam... |
|
T12539L |
Prinomastat
|
KB-R9896,AG3340 |
MMP
|
|
Prinomastat inhibits MMP-2, MMP-3 and MMP-9 (Kis: 0.05 nM, 0.3 nM and 0.26 nM, respectively). Prinomastat crosses the blood-brain barrier. It also has antitumor activity. Prinomastat is a broad-spectrum, potent, orally a... |
|
T9070 |
ASP2905
|
ASP-2905 |
Potassium Channel
|
|
ASP-2905 is a potent and selective inhibitor of potassium channel Kv12.2 encoded by the Kcnh3/BEC1 gene. It can cross the blood-brain barrier and has antipsychotic activities |
|
T71749 |
SF-22
|
|
Neuropeptide Y Receptor
|
|
SF-22 is a neuropeptide Y receptor (Y2R) antagonist that crosses the blood-brain barrier and has potential anti-inflammatory activity for the study of diseases associated with neurological disorders. |
|
T6705 |
TIC10 Isomer
|
ONC201 isomer,TIC10 Analogue |
Others
|
|
TIC10 Isomer (ONC201 isomer) is an isomer of TIC10, which inactivates Akt and ERK to induce TRAIL through Foxo3a, possesses superior drug properties: delivery across the blood-brain barrier, superior stability and improv... |
